Does prophylactic antibiotic administration for tooth extraction affect PT-INR in patients taking warfarin?
نویسندگان
چکیده
منابع مشابه
Delayed complications of tooth extraction in patients taking warfarin, antibiotics, and other medications.
Current published data support treating patients taking warfarin (Coumadin) in a routine manner. First, one should obtain an international normalized ratio (INR) level and then consider the use of enoxaparin (Lovenox) as interim anticoagulant therapy or simply maintain standard warfarin dosage, depending on the complexity of the treatment plan. Combined with intraoperative modalities such as lo...
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Warfarin (WF) shows a number of interactions with other drugs, which alter its anticoagulant effects. The albumin binding interaction is one such pharmacokinetic mechanism of drug interaction with WF, which induces a rise in the free WF concentration and thus increases the risk of WF toxicity. Teicoplanin (TEIC) is an anti-methicillin-resistant Staphylococcus aureus drug, which also binds stron...
متن کاملFactors that affect rate of INR decline after warfarin discontinuation.
BACKGROUND Despite vast literature on warfarin, optimal strategies for temporarily discontinuing and restarting warfarin have not been established. To improve warfarin discontinuation processes, we investigated known medical and genetic factors that influence stable warfarin dose to determine how well they predict the time until patients become subtherapeutic after discontinuing warfarin. MET...
متن کاملEffect of single-dose extended-release oral azithromycin on anticoagulation status in warfarinized patients.
OBJECTIVE The aim of this study was to investigate the possible influence of single-dose 2.0-g azithromycin (AZ-ER) on anticoagulation in patients taking warfarin. STUDY DESIGN Eighteen consecutive patients receiving long-term stable warfarin therapy were enrolled in this study. AZ-ER was administered 1 hour prior to tooth extraction. The international normalized ratio (INR) value was measure...
متن کاملHigh INR on warfarin.
A 72 year old woman, who had been diagnosed as having recurrent deep vein thrombosis six weeks earlier, attends the practice’s phlebotomy clinic for an international normalised ratio (INR) check. Her INR is greater than 8.0 (target INR range: 2.0-3.0). During the consultation, you look through her previous INR readings and notice they have been supra-therapeutic over the past two weeks despite ...
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ژورنال
عنوان ژورنال: BMC Oral Health
سال: 2020
ISSN: 1472-6831
DOI: 10.1186/s12903-020-01326-w